Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children: An Update
Identifieur interne : 003041 ( Main/Exploration ); précédent : 003040; suivant : 003042Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children: An Update
Auteurs : Stephen M. Graham [Australie, France] ; Luis E. Cuevas [Royaume-Uni] ; Patrick Jean-Philippe ; Renee Browning [États-Unis] ; Martina Casenghi [Suisse] ; Anne K. Detjen [France] ; Devasena Gnanashanmugam [États-Unis] ; Anneke C. Hesseling [Afrique du Sud] ; Beate Kampmann [Royaume-Uni, Gambie] ; Anna Mandalakas ; Ben J. Marais [Australie] ; Marco Schito ; Hans M. L. Spiegel ; Jeffrey R. Starke ; Carol Worrell [États-Unis] ; Heather J. Zar [Afrique du Sud]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Tuberculose, Tuberculose pulmonaire.
- microbiologie : Tuberculose, Tuberculose pulmonaire.
- Consensus, Enfant, Enfant d'âge préscolaire, Humains, Mâle, Normes de référence, Thorax, Tuberculose.
English descriptors
- KwdEn :
- MESH :
- classification : Tuberculosis.
- diagnosis : Tuberculosis, Tuberculosis, Pulmonary.
- microbiology : Tuberculosis, Tuberculosis, Pulmonary.
- Child, Child, Preschool, Consensus, Humans, Male, Reference Standards, Thorax.
Abstract
Consensus case definitions for childhood tuberculosis have been proposed by an international expert panel, aiming to standardize the reporting of cases in research focusing on the diagnosis of intrathoracic tuberculosis in children. These definitions are intended for tuberculosis diagnostic evaluation studies of symptomatic children with clinical suspicion of intrathoracic tuberculosis, and were not intended to predefine inclusion criteria into such studies. Feedback from researchers suggested that further clarification was required and that these case definitions could be further improved. Particular concerns were the perceived complexity and overlap of some case definitions, as well as the potential exclusion of children with acute onset of symptoms or less severe disease. The updated case definitions proposed here incorporate a number of key changes that aim to reduce complexity and improve research performance, while maintaining the original focus on symptomatic children suspected of having intrathoracic tuberculosis. The changes proposed should enhance harmonized classification for intrathoracic tuberculosis disease in children across studies, resulting in greater comparability and the much-needed ability to pool study results.
Url:
DOI: 10.1093/cid/civ581
PubMed: 26409281
PubMed Central: 4583568
Affiliations:
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Graham</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Centre for International Child Health, University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute</addr-line><institution>, Royal Children's Hospital</institution>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>International Union Against Tuberculosis and Lung Disease</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Burnet Institute</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cuevas, Luis E" sort="Cuevas, Luis E" uniqKey="Cuevas L" first="Luis E." last="Cuevas">Luis E. 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Graham</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Centre for International Child Health, University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute</addr-line><institution>, Royal Children's Hospital</institution>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>International Union Against Tuberculosis and Lung Disease</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Burnet Institute</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cuevas, Luis E" sort="Cuevas, Luis E" uniqKey="Cuevas L" first="Luis E." last="Cuevas">Luis E. Cuevas</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Clinical Sciences</addr-line>,<institution>Liverpool School of Tropical Medicine</institution>,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jean Philippe, Patrick" sort="Jean Philippe, Patrick" uniqKey="Jean Philippe P" first="Patrick" last="Jean-Philippe">Patrick Jean-Philippe</name><affiliation><nlm:aff id="af5"><addr-line>Henry M. Jackson Foundation</addr-line></nlm:aff></affiliation></author><author><name sortKey="Browning, Renee" sort="Browning, Renee" uniqKey="Browning R" first="Renee" last="Browning">Renee Browning</name><affiliation wicri:level="2"><nlm:aff id="af6"><addr-line>Division of AIDS</addr-line>,<institution>National Institute of Allergy and Infectious Diseases, National Institutes of Health</institution>,<addr-line>Rockville, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Casenghi, Martina" sort="Casenghi, Martina" uniqKey="Casenghi M" first="Martina" last="Casenghi">Martina Casenghi</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Médicins Sans Frontières, Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Detjen, Anne K" sort="Detjen, Anne K" uniqKey="Detjen A" first="Anne K." last="Detjen">Anne K. Detjen</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>International Union Against Tuberculosis and Lung Disease</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gnanashanmugam, Devasena" sort="Gnanashanmugam, Devasena" uniqKey="Gnanashanmugam D" first="Devasena" last="Gnanashanmugam">Devasena Gnanashanmugam</name><affiliation wicri:level="2"><nlm:aff id="af6"><addr-line>Division of AIDS</addr-line>,<institution>National Institute of Allergy and Infectious Diseases, National Institutes of Health</institution>,<addr-line>Rockville, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Hesseling, Anneke C" sort="Hesseling, Anneke C" uniqKey="Hesseling A" first="Anneke C." last="Hesseling">Anneke C. Hesseling</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Desmond Tutu Tuberculosis Centre, Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences</addr-line>,<institution>Stellenbosch University</institution>,<addr-line>Cape Town</addr-line>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kampmann, Beate" sort="Kampmann, Beate" uniqKey="Kampmann B" first="Beate" last="Kampmann">Beate Kampmann</name><affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Department of Paediatrics</addr-line>,<institution>Imperial College London</institution>,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Vaccinology Theme</addr-line>,<institution>MRC Unit</institution>,<country>The Gambia</country></nlm:aff><country xml:lang="fr">Gambie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mandalakas, Anna" sort="Mandalakas, Anna" uniqKey="Mandalakas A" first="Anna" last="Mandalakas">Anna Mandalakas</name><affiliation><nlm:aff id="af11"><addr-line>Department of Pediatrics, Baylor College of Medicine</addr-line>,<institution>Texas Children's Hospital</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Marais, Ben J" sort="Marais, Ben J" uniqKey="Marais B" first="Ben J." last="Marais">Ben J. Marais</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Marie Bashir Institute for Infectious Diseases and Biosecurity) and the Sydney Emerging Infectious Diseases and Biosecurity Institute and The Children's Hospital at Westmead</addr-line>,<institution>Sydney Medical School</institution>,<institution>University of Sydney</institution>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schito, Marco" sort="Schito, Marco" uniqKey="Schito M" first="Marco" last="Schito">Marco Schito</name><affiliation><nlm:aff id="af5"><addr-line>Henry M. Jackson Foundation</addr-line></nlm:aff></affiliation></author><author><name sortKey="Spiegel, Hans M L" sort="Spiegel, Hans M L" uniqKey="Spiegel H" first="Hans M. L." last="Spiegel">Hans M. L. Spiegel</name><affiliation><nlm:aff id="af5"><addr-line>Henry M. Jackson Foundation</addr-line></nlm:aff></affiliation></author><author><name sortKey="Starke, Jeffrey R" sort="Starke, Jeffrey R" uniqKey="Starke J" first="Jeffrey R." last="Starke">Jeffrey R. Starke</name><affiliation><nlm:aff id="af11"><addr-line>Department of Pediatrics, Baylor College of Medicine</addr-line>,<institution>Texas Children's Hospital</institution>,<addr-line>Houston</addr-line></nlm:aff></affiliation></author><author><name sortKey="Worrell, Carol" sort="Worrell, Carol" uniqKey="Worrell C" first="Carol" last="Worrell">Carol Worrell</name><affiliation wicri:level="2"><nlm:aff id="af13"><institution>Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health</institution>,<addr-line>Rockville, Maryland</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Zar, Heather J" sort="Zar, Heather J" uniqKey="Zar H" first="Heather J." last="Zar">Heather J. Zar</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, MRC Unit on Child and Adolescent Health</addr-line>,<institution>University of Cape Town</institution>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Consensus</term><term>Humans</term><term>Male</term><term>Reference Standards</term><term>Thorax</term><term>Tuberculosis (classification)</term><term>Tuberculosis (diagnosis)</term><term>Tuberculosis (microbiology)</term><term>Tuberculosis, Pulmonary (diagnosis)</term><term>Tuberculosis, Pulmonary (microbiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Consensus</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Mâle</term><term>Normes de référence</term><term>Thorax</term><term>Tuberculose ()</term><term>Tuberculose (diagnostic)</term><term>Tuberculose (microbiologie)</term><term>Tuberculose pulmonaire (diagnostic)</term><term>Tuberculose pulmonaire (microbiologie)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Tuberculosis</term><term>Tuberculosis, Pulmonary</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tuberculose</term><term>Tuberculose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Tuberculose</term><term>Tuberculose pulmonaire</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Tuberculosis</term><term>Tuberculosis, Pulmonary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Child, Preschool</term><term>Consensus</term><term>Humans</term><term>Male</term><term>Reference Standards</term><term>Thorax</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Consensus</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Mâle</term><term>Normes de référence</term><term>Thorax</term><term>Tuberculose</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Consensus case definitions for childhood tuberculosis have been proposed by an international expert panel, aiming to standardize the reporting of cases in research focusing on the diagnosis of intrathoracic tuberculosis in children. These definitions are intended for tuberculosis diagnostic evaluation studies of symptomatic children with clinical suspicion of intrathoracic tuberculosis, and were not intended to predefine inclusion criteria into such studies. Feedback from researchers suggested that further clarification was required and that these case definitions could be further improved. Particular concerns were the perceived complexity and overlap of some case definitions, as well as the potential exclusion of children with acute onset of symptoms or less severe disease. The updated case definitions proposed here incorporate a number of key changes that aim to reduce complexity and improve research performance, while maintaining the original focus on symptomatic children suspected of having intrathoracic tuberculosis. The changes proposed should enhance harmonized classification for intrathoracic tuberculosis disease in children across studies, resulting in greater comparability and the much-needed ability to pool study results.</p></div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>France</li><li>Gambie</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Jean Philippe, Patrick" sort="Jean Philippe, Patrick" uniqKey="Jean Philippe P" first="Patrick" last="Jean-Philippe">Patrick Jean-Philippe</name><name sortKey="Mandalakas, Anna" sort="Mandalakas, Anna" uniqKey="Mandalakas A" first="Anna" last="Mandalakas">Anna Mandalakas</name><name sortKey="Schito, Marco" sort="Schito, Marco" uniqKey="Schito M" first="Marco" last="Schito">Marco Schito</name><name sortKey="Spiegel, Hans M L" sort="Spiegel, Hans M L" uniqKey="Spiegel H" first="Hans M. L." last="Spiegel">Hans M. L. Spiegel</name><name sortKey="Starke, Jeffrey R" sort="Starke, Jeffrey R" uniqKey="Starke J" first="Jeffrey R." last="Starke">Jeffrey R. Starke</name></noCountry><country name="Australie"><noRegion><name sortKey="Graham, Stephen M" sort="Graham, Stephen M" uniqKey="Graham S" first="Stephen M." last="Graham">Stephen M. Graham</name></noRegion><name sortKey="Graham, Stephen M" sort="Graham, Stephen M" uniqKey="Graham S" first="Stephen M." last="Graham">Stephen M. Graham</name><name sortKey="Marais, Ben J" sort="Marais, Ben J" uniqKey="Marais B" first="Ben J." last="Marais">Ben J. Marais</name></country><country name="France"><noRegion><name sortKey="Graham, Stephen M" sort="Graham, Stephen M" uniqKey="Graham S" first="Stephen M." last="Graham">Stephen M. Graham</name></noRegion><name sortKey="Detjen, Anne K" sort="Detjen, Anne K" uniqKey="Detjen A" first="Anne K." last="Detjen">Anne K. Detjen</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Cuevas, Luis E" sort="Cuevas, Luis E" uniqKey="Cuevas L" first="Luis E." last="Cuevas">Luis E. Cuevas</name></noRegion><name sortKey="Kampmann, Beate" sort="Kampmann, Beate" uniqKey="Kampmann B" first="Beate" last="Kampmann">Beate Kampmann</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Browning, Renee" sort="Browning, Renee" uniqKey="Browning R" first="Renee" last="Browning">Renee Browning</name></region><name sortKey="Gnanashanmugam, Devasena" sort="Gnanashanmugam, Devasena" uniqKey="Gnanashanmugam D" first="Devasena" last="Gnanashanmugam">Devasena Gnanashanmugam</name><name sortKey="Worrell, Carol" sort="Worrell, Carol" uniqKey="Worrell C" first="Carol" last="Worrell">Carol Worrell</name></country><country name="Suisse"><noRegion><name sortKey="Casenghi, Martina" sort="Casenghi, Martina" uniqKey="Casenghi M" first="Martina" last="Casenghi">Martina Casenghi</name></noRegion></country><country name="Afrique du Sud"><noRegion><name sortKey="Hesseling, Anneke C" sort="Hesseling, Anneke C" uniqKey="Hesseling A" first="Anneke C." last="Hesseling">Anneke C. Hesseling</name></noRegion><name sortKey="Zar, Heather J" sort="Zar, Heather J" uniqKey="Zar H" first="Heather J." last="Zar">Heather J. Zar</name></country><country name="Gambie"><noRegion><name sortKey="Kampmann, Beate" sort="Kampmann, Beate" uniqKey="Kampmann B" first="Beate" last="Kampmann">Beate Kampmann</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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